Mildronate Health Effects
Mildronate is an anti-ischemic drug developed for the treatment of cardiac ischemia, angina pectoris, ischemic cardiomyopathy and chronic heart failure. It has also found use in therapy in acute cerebrovascular insufficiency and in recovery after cerebral circulatory disorders and head trauma.
Mildronate acts by regulating energy metabolism, lowering the levels of L-carnitine, an amino acid, in order to prevent the accumulation of toxic intermediates.
Today it can be considered reasonably certain that the effect of meldonium can be traced to the mitochondria (the cell’s “power plant”), which is interesting because mitochondria are present in all cells in the body, which makes it possible that meldonium affects all organs in the body that could benefit from a better energy metabolism. This has been used to some extent in studies of neurons and thus there are small studies (or hypotheses) about using the preparation after stroke as well as at Parkinson’s and Alzheimer’s Diseases. However, one cannot see that there are scientific results that show that the preparation has some effect in these contexts.
There is a report claiming that Mildronate increases the alertness and another that the learning ability increases. Mildronate’s mechanism of action is linked to carnitine, which is a substance studied not least in sports contexts as dietary supplements. Carnitine is a transport molecule that is linked to the transport of long fatty acids across the inner mitochondrial membrane. One source of carnitine is meat, but carnitine can also be self-synthesized from the amino acids lysine and methionine.
Mildronate (both in short-term and long-term studies) reduces the carnitine content of the blood (in one four week study 18%) since mildronate inhibits the biosynthesis of carnitine and thus works as an inhibitor of the fatty acid oxidation. This affects the speed of the cell energy metabolism.
Mildronate has the following actions:
In general, Mildronate has a positive effect on the body, manifested in improving performance, reducing over-voltage, both mental and physical. Also, the drug increases the level of humoral and cellular immunity.