How does Meldonium work?

Meldonium is an active ingredient of Mildronate pills. The preparation is applied in complex therapy of ischemic heart disease, chronic heart failure, myocardial infarction and stroke. In addition, Mildronate is prescribed to the patients with physical and emotional exhaustion for bettering their general performance. Besides, Meldonium is also effective for speeding up the recovery of individuals with traumas of head and those with various blood circulation issues (like ocular ischemic syndrome).

Some people use Mildronate off-label for stimulating physical power and endurance. It is especially relevant for athletes.

How does Meldonium work?

Mildronate drug information on the mechanism of its action is quite limited as the number of reputable clinical trials concerning this question is very low.  Nevertheless, Meldonium is known to affect carnitine biosynthesis. Carnitine transports fatty acids to the cells of the human body. After being oxygenated, they transform into energy needed for a healthy organism functioning.

Nevertheless, when a human body is working under load (e.g. doing sports), the cells may lack oxygen for a complete oxygenation of fats. It results in the appearance of activated forms of unoxidized fatty acids, which may have a harmful effect on the cell membranes.

Mildronate reduces the amount of carnitine and, hence, fatty acids in the cells, making them use carbohydrates for the energy synthesis. Their oxygenation demands less oxygen thus providing the cells not only with the needed amounts of nutrients and oxygen but also optimizes their usage.

What effects does Meldonium induce?

The intake of Mildronate 500mg dosage daily may produce such effects:Meldonium has nootropic effect

  • Protection of heart muscle from overload;
  • Enhancement of cerebral blood flow;
  • Normalization of heart rhythm and breathing when under load;
  • Improvement of nerve reaction;
  • Lowering of probability of hypoxia (lack of oxygen);
  • Endurance increase;
  • Shortening of time needed to recover from physical load;
  • Reduction of the area of tissue damage in case of infarction or stroke;
  • Stress resistance.

Taking into account all the effects, which may be expected after the drug intake, one may draw a conclusion that Meldonium has nootropic effect and may be used as a stimulant drug. Due to such properties of the medication, in 2016 it was banned by the World Anti-Doping Agency from use by sportsmen.

What unwanted reactions may be expected?

Meldonium is a preparation, which is not approved by FDA. Actually, the use of this drug is permitted only in a limited number of countries because of lack of trustworthy clinical trials on people. Hence, the whole spectrum of its possible side effects is not clear. Some of them are known:Meldonium Indian brand

  • Allergy to Meldonium or any other inactive ingredient of the medication;
  • Anxiety, insomnia;
  • Vertigo, headache, faintness, loss of consciousness;
  • Pain or discomfort in chest, arrhythmia, tachycardia;
  • Diarrhea, nausea, stomachache, loss of appetite;
  • Muscle spasms, back pain.

Therapy with Meldonium is considered quite safe, but its long-term effects are still poorly studied. So, you’d betted consult your healthcare provider to learn more about all the possible pros and cons of Meldonium Indian brand intake for your health.