Active Substance & Action Mechanism
According to the scientific literature, Mildronate emerged in Latvia in the 1970s in trials to increase the growth rate of meat animals. On February 15, 2016, PubMed has a total of 215 articles above keywords. The first was published in 1986 by Latvian researchers and concerned the metabolism in the heart, where it was shown that Mildronate improved energy metabolism in heart muscle cells. Additional 8 articles were published in Russian before the first came out – still with Russian authors – in English in 1988. Two Japanese articles in English were published in 1989, but before 1997 there were only two articles from Japan compared to 49 from Latvia, Russia and Ukraine.
From the year 2000, it can be established that the cardioprotective effect of the mesonium is well dispersed in Japan, from which a number of articles on experiments were published mainly in rats.
Dosage & Posology
Meldonium is taken with meals with sufficient amount of water. Dosages and posology are strictly individual and decided upon by the doctor. Here is a general scheme:
Cardiovascular disorders (in association with other drugs): 500-1000mg in one-two daily administrations for 4-6 weeks.
Chronic cerebrovascular disorders: 500mg once a day for 4-6 weeks.
Psycho-physical stress: 250mg four times a day for 10-14 days.
Withdrawal syndrome in chronic alcoholism (in combination with other drugs): 500mg four times a day for 7-10 days.
Given that the drug should be taken only in accordance with medical prescription, the dose must be adapted based on the need, in particular it should be reduced in elderly patients, as well as patients with moderate renal and / or hepatic insufficiency.